The metabolic basis of nonalcoholic steatohepatitis
نویسندگان
چکیده
منابع مشابه
Nonalcoholic steatohepatitis and the metabolic syndrome.
Nonalcoholic fatty liver disease (NAFLD) is a major form of chronic liver disease in adults and children. It is one of the consequences of the current obesity epidemic, and can progress to nonalcoholic steatohepatitis (NASH), characterized by steatosis, inflammation, and progressive fibrosis, ultimately leading to cirrhosis and end-stage liver disease. The factors implicated in this progression...
متن کاملMechanistic basis of altered morphine disposition in nonalcoholic steatohepatitis.
Morphine is metabolized in humans to morphine-3-glucuronide (M3G) and the pharmacologically active morphine-6-glucuronide (M6G). The hepatobiliary disposition of both metabolites relies upon multidrug resistance-associated proteins Mrp3 and Mrp2, located on the sinusoidal and canalicular membrane, respectively. Nonalcoholic steatohepatitis (NASH), the severe stage of nonalcoholic fatty liver di...
متن کاملNonalcoholic steatohepatitis.
Nonalcoholic fatty liver disease (NAFLD) is being increasingly recognized as a common liver disorder that represents the hepatic manifestation of the metabolic syndrome, a variably defined aggregate of disorders related to obesity, insulin resistance, type II diabetes, hypertension and hyperlipidemia. Nonalcoholic steatohepatitis (NASH) is the progressive form of liver injury that carries a ris...
متن کاملModel of nonalcoholic steatohepatitis.
BACKGROUND Obesity and diabetes are frequently associated with nonalcoholic steatohepatitis (NASH), but studies have been hampered by the absence of a suitable experimental model. OBJECTIVE Our objective was to create a rat model of NASH. DESIGN Sprague-Dawley rats were fed a high-fat, liquid diet (71% of energy from fat, 11% from carbohydrates, 18% from protein) or the standard Lieber-DeCa...
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ژورنال
عنوان ژورنال: Endocrinology, Diabetes & Metabolism
سال: 2020
ISSN: 2398-9238,2398-9238
DOI: 10.1002/edm2.112